Tumor-suppressor genes versus Proto-oncogenes.
This is a library-research topic in which you are required to provide your sources. Mutations in tumor suppressor genes can contribute to or cause cancer, just as mutations in proto-oncogenes can also contribute to or cause cancer. However, tumor suppressor genes are very different from proto-oncogenes.
(a) Explain why a gain-of-function mutation to a proto-oncogene (or its promoter) may be associated with increased risk of cancer.
(b) Explain why a loss-of-function mutation to a tumor suppressor gene may be associated with increased risk of cancer.
References:
Khan Academy, No date given. Apoptosis
, https://www.khanacademy.org/science/biology/cellular-molecular-biology/stem-cells-and-cancer/v/apoptosis
Lindsey Valich, April 19, 2018. Scientists discover gene controlling genetic recombination rates. http://www.rochester.edu/newscenter/genetic-recombination-selfish-dna-may-help-explain-differences-in-fruit-flies-312422/
