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  1. Consider some of the results that are likely to come from the Harvard Nurses’ Health Study over the next 10 to 20 years. What types of results do you think will be most important? Do you think the findings will alter the way you live your life?
  2. Explain why the Harvard Nurses’ Health Study is an observational study and not an experiment. Why do you think this is and discuss whether it would be possible to gather similar data by carrying out experiments in a practical and ethical way?
  3. The Harvard Nurses’ Health Study is subject to participation bias because only 120,000 of the original 370,000 questionnaires were returned. Should the researchers be concerned about this bias? Do you think that dishonesty can affect this type of observational study? Why or why not?
  4. What is the population of interest for this study? What is the sample? Does the population include males? Do you think that the results can be used to make direct inferences about men? Why or why not?

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